Effects of physical stress test on blood pressure, heart rate, rate-pressure-product and double product in normotensive subjects with or without family history of hypertension

Amita M. Pardeshi, Sunanda Kirtikar, N. and Shenvi D.N.

Background: Cardiovascular diseases (CVD) are the number one killer of modern humankind. And in this, hypertension is a noncommunicable, major silent disease. Rate pressure product (RPP) and Double product (DoP) is an important hemodynamic parameter which reflects myocardial oxygen demand and workload. It varies with exercise. Objective: To find out possible alteration in BP, HR, RPP and DoP in normotensive subjects with or without family history of hypertension. Materials and Methods: The study was conducted on total 120 participants, 60 in control and 60 in test group. Cardiovascular response to stress was determined by Harvard step test. Heart rate (HR), blood pressure, RPP and DoP response to exercise were measured in supine position before exercise and at 1, 2, 3, 4, 5, 7 and 10 minutes after the exercise. The results were expressed as Mean ± SD and analyzed using Independent t- test (unpaired t-test) for comparison between the control group and the test group and one way ANOVA test Results: The “P” value < 0.05 was considered statistically significant. Physical stress induced changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), RPP & DoP were found to be significantly higher in normotensive individuals with family history of hypertension as compared to normotensive individuals without family history of hypertension. Conclusion: The present study suggest that increased in blood pressure, heart rate, RPP and DoP in normotensive individual with F/H/O, which in turn increases the risk of CV dysfunction (Hypertension) in these subjects by increasing their myocardial energy expenditure.

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